Changing software to understand and treat autism: the importance of studying maternity and birth

First published in Médecine & Sciences The data on autism are well known: the impact is strong, because -with an incidence of 1,4%- this disease affects communication, which an essential function at the heart of our modern societies. And yet, despite the successive “autism plans” and the sometimes huge sums invested (hundreds of millions of … Read more

Why is it so difficult for politicians to understand scientific research?

First published in french in Médecine et Sciences Research funding suffers from well-known but not understood by generations of politicians’ issues. We are still far from the 3% of GDP required to get back on the saddle and which are occasionally promised before one election or another. However, even those who complain that the rank … Read more

An excitatory GABAergic pathway allows the sodium to regulate our clock time

A new study, published in Nature by researchers from McGill University, shows that increased sodium concentration in the blood may influence the circadian rhythm of mice via an excitatory GABAergic pathway. Our circadian rhythm is controlled by the suprachiasmatic nucleus (SCN), which coordinates physiological and behavioral changes to anticipate changes related to our 24-hour cycle. … Read more

Fake news: earthworms can replace animal testing on mammals

We live in a great world! Our goal is to simplify everything, to quickly diagnose diseases with genetics and big data, and now, we don’t even need to go through preclinical studies on mammals. These wonderful worms with a thousand cells, a super simple nervous system compared to the trillions of connections in the human … Read more


Following the recent publication of a paper called “GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease“, Erwan Bézard, director of the Neurodégénérative Diseases Institute of Bordeauxpublished a commentary, that you can find here. Here’s our answer: First of all, we always pay attention to discussions and criticisms and we welcome … Read more

Bumetanide strikes again in the arena of neurological disorders: a novel therapeutic approach to treat Parkinson’s disease

A new study led by Prs. Yehezkel Ben-Ari & Constance Hammond (Neurochlore and B&A Therapeutics, Marseille, France) demonstrates that bumetanide, an antagonist of the NKCC1 chloride importer, normalizes the activity of neurons in the striatum and alleviates motor impairment in a mouse model of Parkinson’s disease. These findings corroborate the results of a pilot clinical … Read more

Plea for biomedical innovation

A large part of the therapeutic applications of biomedical research is generated in innovation incubators. More than 70% of new drugs come from discoveries made by small structures close to academic research, which have a greater capacity for innovation than larger companies. These ones invest in start-ups by buying them or acquiring licenses. With a … Read more

Technology is a useful servant but a dangerous master

The Paper of Yves Frégnac in Science raises major issues that are on the convergence of the paucity of concepts in science, the evaluation and financing of scientific investigations and the false promises of big programs to understand the brain and treat neurological and psychiatric disorders. The incredible acceleration of technological advances attested every day … Read more

Scientific fraud: when «publish or perish » leads to the distortion of reality

The increase of scientific frauds and publications that are not reproductible is a major concern that has been analyzed many times. So-called leading journals have more and more retractations, articles considered major and opening up new perspectives are abandoned because based on tampered or “arranged” results, even emanating from prestigious laboratories. These frauds, however, have … Read more

Why is it so hard to reform scientific research?

In a refreshing article, an American scientist proposes a series of changes to improve the functioning of the National Institutes of Health (NIH), one of the leading scientific research institutions in the US. Despite the differences in the organization of science in the US and Europe, it is interesting to note the similarity in the criticisms … Read more

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