3D atlas of the mouse brain before and after birth

Many disorders are born in utero including Autism and many neurodevelopmental disorders. to understand hos they are generated and whether and how brain structures are impacted already in utero, it is instrumental to develop quantitative atlases of brain structures. IN this aim, we used the recently developed transparization (I disco) technique that enable to dissolve … Read more

IBEN hosts a satellite conference at FENS 2022

IBEN will give a satellite conference at the FENS 2022, an european congress of neurosciences. The conference, which take place on July 7 and 8 at RIVE Montparnasse, will focus on the Neuroarcheology of the brain disorders and GABA signals. It will be organized by Yehezkel Ben-Ari & Nick Spitzer and will include many renowed … Read more

Bumetanide to treat brain disorders: when the empire strikes back!

Our attempts to treat children with Autism Spectrum Disorders (ASD) with the NKCC1 chloride importer antagonist have met with some success with several hundreds of children treated successfully in several trial made in France, China, Sweden, Great Britain, Holland and Tunisia. Yet a large phase 3 (400 children in Europe, Brazil, Australia and US) failed. … Read more

There is not a single Autism-specific gene, just brain genes !

For decades, we have been repeatedly informed as an undisputable fact that Autism Spectrum Disorders (ASD) are “genetic”, with genetic mutations being responsible for 15 then 25% and probably all ASD. This more technical than conceptual approach has not led to a single treatment even at early stages, and no significant novel understanding of how … Read more

Use of machine learning to identify at birth babies at risk of developing Autism Spectrum Disorders

Autism Spectrum Disorders (ASDs) are associated with socialization and communication problems as well as restricted interests and stereotypic behavior. The diagnosis is usually obtained around 3-5 years old, yet we know that early psycho-educative methods enable to attenuate the severity of ASDs in particular if they are utilized early on. Since ASDs are “born” in … Read more

Of mice and men: how studying brain development helps developing treatments of autism

Basic science: In 1989 we discovered that adult and immature neurons have different electrical activity with notably much lower intracellular concentrations of chloride in the former than in the latter. High levels of chloride lead to a reduced brain inhibition and increased excitation, and are observed in immature neurons of all animal species and brain … Read more

Failed study of bumetanide in Autism: limitations of the Dutch trial and what does it means for bumetanide treatment

Bruining and colleagues reported, in a 3-month mono-centric trial in 92 verbal ASD children (7-15 years old) without severe mental disability, that bumetanide did not significantly attenuate the severity of autism. This trial is at odds with 5 earlier trials from 3 independent groups who reported significant ameliorations. Astonishingly, the same group reported earlier that … Read more

Changing software to understand and treat autism: the importance of studying maternity and birth

First published in Médecine & Sciences The data on autism are well known: the impact is strong, because -with an incidence of 1,4%- this disease affects communication, which an essential function at the heart of our modern societies. And yet, despite the successive “autism plans” and the sometimes huge sums invested (hundreds of millions of … Read more

Comment on the paper published by Lingli Zhang et al. in Translational Psychiatry

We are grateful to this group to have confirmed our earlier results published in 2012 and 2017 using exactly similar protocol and evaluation. This is the 3rd paper validating our approach that is now the basis for an FDA/EMA approved large worldwide phase 3 trials conducted with Servier. The current publication also provides some support … Read more

Foetal oestrogens and autism

Scientists have identified a link between exposure to high levels of oestrogen sex hormones in the womb and the likelihood of developing autism. This study, published in the journal Molecular Psychiatry, support the idea that increased prenatal sex steroid hormones are one of the potential causes of autism. It follows on from a first study … Read more

New paper: Fetal brain volume increases during parturition and birth in autism

Cloarec et al, Pyramidal neurons growth and increased hippocampal volume during labor and birth in autism, Science Advances, 23rd January 2019 Yehezkel Ben-Ari and Neurochlore team demonstrate for the first time that in a naive animal, cortical and neuronal volume are not impacted by labor and birth. In contrast, in an animal model of autism, … Read more

White paper on Autism Spectrum Disorder

This White Paper, written by renowned scientists, is aimed at all stakeholders, all societies, their government and their media, for a global awareness. It will widely disseminate valuable knowledge for a coherent and rational public action, of interest for the public health and also of interest for the improvement of the human condition of the … Read more

At birth neurons are bigger following Maternal Immune Activation

Amandine Fernandez, Camille Dumon, Damien Guimond, Roman Tyzio, Paolo Bonifazi, Natalia Lozovaya, Nail Burnashev, Diana C Ferrari, Yehezkel Ben-Ari; The GABA Developmental Shift Is Abolished by Maternal Immune Activation Already at Birth, Cerebral Cortex, novembre 2018 Article online Maternal Immune Activation (MIA) is due to an intrauterine infection that perturbs the immune system leading to the … Read more

When leptin and metabolism impact the actions of GABA on immature neurons

An interesting observation linking metabolism with the GABA developmental shift and developmental disorders. Studying the well characterized GABA developmental shift with excitatory actions of GABA on immature neurons and inhibitory ones in adults, J-L Gaiarsa, C Porcher and colleagues have tested the hypothesis that metabolism and a major hormone controlling it -leptin- impact the time … Read more

Chloride, homeopathy, scientism and autism

The spectrum of autistic syndromes is composed of very different syndromes, which often causes diagnostic problems and explains both our very partial understanding of the underlying mechanisms and the fact that there is currently no medication approved by the European and American authorities. This also explains why clueless mothers – and this is easily understandable … Read more

An answer to Prof Tepper about his short comment on our recently published paper

We recently published a paper called “GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease“. Prof Tepper briefly commented it on Twitter. Here’s our answer:   Our paper is not some sort of “artefact”. Things are never so simple, they usually have an explanation. The devil, as we all know, … Read more

Bumetanide for autism: more eye contact, less amygdala activation

Bumetanide for autism: more eye contact, less amygdala activation Nouchine Hadjikhani (Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, Etats-Unis et Université de Gothenburg, Gothenburg, Suède), Eric Lemonnier (Centre Hospitalier Universitaire, Limoges, France) et Yehezkel Ben-Ari (Neurochlore, Marseille, France) One of the permanent features of autistic patients is the fear of looking at the … Read more

Childbirth and the multiple facets of a hormone : oxytocin

The birth process took millions of years to be developed. It must allow 4 major reactions: a passage from an immunologically protected environment to the external environment, the acquisition of microbes in its digestive system, the transition from a temperature of 38 ° to colder external temperatures and especially the evacuation of the water molecules … Read more

Sanofi and the case of the sodium valproate

Overwhelming testimonies about the Sanofi and health officials disaster on the case of sodium valproate The dangers of this molecule has been known for at least 3 decades, resulting in life-long sequelae of children with autism, delayed development, drug-resistant epilepsy seizures, etc. These emotional and overwhelming testimonies show both the importance of the commitment of … Read more

Two articles establish the link between in utero development, inflammation, microbiota and autism

Since the classical work of the late Paul Patterson, it is known that the activation of the immune system during the intrauterine period produces an autistic syndrome by activating the immune system and causing the release of inflammatory molecules such as interleukins which will impact the cerebral maturation. It is also known that in rodents … Read more

For people with autism, avoiding eye contact could be due to something other than indifference

Individuals with autism spectrum disorder (ASD) often find it difficult to look others in the eyes, and we don’t exactly know why. What could be granted for indifference could actually have a completely different explanation. Indeed, according to Nouchine Hadjikhani, cofounder of Neurochlore and director of the Neurolimbic Research Laboratory in the Martinos Center in … Read more

The dilemma of the pain in the newborn

  Curiously we know a lot on pain of the mother during delivery but much less that of the new born. Several techniques and drugs can infirm the biblical saying –thou shall deliver in pain –and that is of course important. Yet, we should not forget that the partner of this incredibly complex event, namely … Read more

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