Research conducted by the late Paul Patterson (University of California) had shown that the incidence of autism increased in the population following widespread outbreaks of viral infections. Using animal models, he demonstrated that infecting a pregnant mouse with the influenza virus caused a syndrome resembling autism and schizophrenia—with all the limitations inherent in what such … Read more
In my previous articles, I discussed the limitations of genetics in explaining autism and the importance of environmental factors—particularly pesticides during pregnancy. I then addressed the complex issue of epigenetics—the environmental regulation of gene activation or inactivation—an essential process that does not involve changes to the DNA sequence. This is a “non-sequential” form of control, … Read more
More than 250 years ago, Linnaeus observed changes in floral symmetry that were passed down through several generations. Two centuries later, it was discovered that this change was not due to a genetic mutation but rather to genetic regulation mediated by what has since been termed epigenesis—the factors that control the activation or inactivation of … Read more
In a previous chapter, I illustrated how pesticides can affect brain development and lead to autism. Here, before continuing the discussion of the long list of factors that can lead to the same outcomes, I’ll revisit the key principles of brain maturation to better understand how these factors come into play and result in developmental … Read more
As I wrote in a previous blog post, Autism Spectrum Disorders (ASDs) “originate” in utero, as we demonstrated five years ago. By retrospectively analyzing data collected in maternity wards (more than 150 non-genetic parameters) using machine learning, we can identify at birth nearly half of the babies who will have autism and all those who will … Read more
In our article published in the *Journal of Medical Genetics*, Etienne Danchin and I addressed the issue of genetics dominating the field of autism. Our aim was to challenge the simplistic claims found in the scientific literature and mainstream media—that “autism is X% genetic” (often cited as 80%!). While it is true that a small … Read more
For several years now, I have been working with my colleagues on treatments for autism and various brain diseases and tumors based on the loss of brain inhibition. At the heart of this system is the regulation of intracellular concentrations of various ions, particularly chloride levels. As I have summarized many times, these levels largely … Read more
Since Thomas Bourgeron (Institut Pasteur) identified a genetic mutation linked to autism some twenty years ago, several hundred mutations have been suggested as contributing to this syndrome. Autism Spectrum Disorder (ASD) has since been classified as a genetically based syndrome, disregarding the major role of the environment. Yet despite repeated promises, and unless I am … Read more
Detecting autism at birth and identifying children likely to respond to treatment: long out of reach, these prospects are becoming concrete thanks to artificial intelligence. Driven by my work, two major French advances, both world firsts, could transform the early care and treatment of autism spectrum disorders (ASD), which affect approximately 1 in 127 children … Read more
While there is still no approved drug treatment to reduce the main symptoms of autism, a study published in the journal Translational Psychiatry shows that artificial intelligence could be a game changer. By reanalyzing data from large clinical trials previously considered negative using machine learning algorithms, researchers show that, when certain clinical profiles are taken into account, … Read more
Five French hospitals are joining the Pelargos project, led by B&A Biomedical, to revolutionize early screening for autism by analyzing data collected in maternity wards. This new step marks a decisive advance towards the large-scale validation of this artificial intelligence system. With Pelargos, France is on track to become the first country in the world … Read more
“Yehezkel Ben-Ari: The Neuroarcheology concept: From brain development to predicting, understanding, and treating brain disorders”. This is the title of an interview published by Genomic press as part of a series of portraits dedicated to the scientific and personal life of well-known scientists. it is always amazing and difficult to bring together personnal and professional … Read more
I am delighted to announce the creation of a corporate hotel on the Luminy campus – the Ben-Ari Institute for Innovation (IBEN) – which will be built by Eiffage with Rudy Ricciotti as architect and Tivoli Capital as the main financier. With 6,600 square metres of laboratories, offices and common areas, it will be a … Read more
In this work (1), the authors examined the possible relationships between metabolism and food consumed during pregnancy, and in particular during the 24th week (approximately 6 months of gestation), and the incidence of neurodevelopmental diseases such as autism and ADHD. The study examined the development of children at the age of 10 in a cohort … Read more
I am pleased to announce the publication, with my friend Etienne Danchin, of an article that criticizes the genetic view of autism and shows why we cannot ignore the crucial role of the environment during pregnancy. In our opinion, the dominance of the genetic view of autism for decades is not only based on questionable … Read more
As part of an exceptional conference organized by the Rotary Club la Ciotat Ceyreste, I will have the honor of presenting my work on autism and prenatal brain dysfunctions. Entitled “Predicting and treating autism through the concept of neuroarchaeology”, this conference will highlight fundamental discoveries that could transform the understanding and treatment of neurodevelopmental disorders. … Read more
One of the aims of both political and medical authorities is to diagnose neurodevelopmental syndromes such as autism as early as possible. Behavioural treatments are all the more effective if they start early, during the pivotal period of plasticity and learning in the first 2-3 years of life. In France, as in most other European … Read more
Despite considerable efforts and substantial investment, there are still no effective treatments for many neurological and psychiatric diseases, including autism and other developmental syndromes. There are 2 main reasons for this I) These syndromes are born in utero, which modifies the pathogenesis of the syndrome. As I have already explained, the triggering element will modify … Read more
Founded 5 years ago by the Neurochlore start-up, the non-profit IBEN fund aimed to help parents of autistic children and autism support associations. Over the 5 years of its existence, based exclusively on donations from Neurochlore, we have been able to distribute over €150K to various associations across the country, including Abashoshin , Asperanza (Brest) … Read more
In the space of 1000 days (270 days of pregnancy + 365 days for the child’s first year + 365 days for its second year), the baby will undergo incredible development! He will learn his mother tongue in utero, crawl to the breast on the day of birth, look, smile, sit, crawl, stand, walk, talk…During … Read more
I’m taking part in this meeting with the heads of CHU and innovation. I’ll be presenting our advances in the “Pelargos” project. In a nutshell, autism is “born” in utero, resulting in changes to the way the brain is constructed and later manifesting itself as the syndrome and its characteristics. As a result, we set … Read more
Prof. Yehezkel Ben-Ari will participate in BIO Europe meeting in Stockholm early November to develop partnerships with Pharma’s & investors to treat autism and brain tumors.The Co-transporter NKCC1 that regulates GABAergic inhibition and cell volume is overactive in many brain disorders including autism, fragile X and Rett syndrome, brain trauma, epilepsies, brain traumas cerebro-vascular infarcts, … Read more
The spectrum link is a large communication network involved in describing and reporting novel tools to understand and treat autism spectrum Disorders (ASD). Their correspondent has asked me to give a teamviews lecture on my observations and discovery on novel approaches and treatments of autism. I have taken this opportunity to describe several issues that … Read more
The starting point for this adventure is the well-established observation that Calcium requirements for breastfeeding generate a loss of bone formation, estimated at 10% in women and 30% in female rodents. Normally, nature is well done, estrogens compensate for this by slowing down bone resorption – remember that 3 types of bone cells contribute to … Read more
It will soon be 10 years that I have been offering this treatment for children with autism spectrum disorders with my friend Eric Lemonnier. Including our 2 successful inaugural phase 2 clinical trials, 7 other trials have been carried out around the world with, according to a meta-analysis, more than 1036 children successfully treated (Xiao … Read more
Dr Chedotal’s team (Paris Vision Institute) has already demonstrated its extraordinary abilities to study brain maturation with a tool that it masters and uses masterfully: the Light Sheet Microscope. Exploiting his proximity to hospitals and the links he has patiently developed over several years, Alain Chedotal was able to have access to human embryos (termination … Read more
To treat autism, I have often insisted on the importance of determining the electrical modifications, particularly the inaugural pathological event which occurs in utero. The concept of neuroarchaeology states that these initial events result in the persistence of neurons that remain immature – which do not mature and which disrupt brain functioning. We have thus … Read more
We like simple things in the modern, digital world, white or black, 0 or 1! Autism is either the fault of the mother or poor genetics. But both are false! the idea of the mother’s fault was born in the mind of a twisted psychologist, which has no scientific basis, if only because the syndrome … Read more
A systematic investigation of fertility around the world has recently been performed relying on 8709 country -years vital and sample registration. Age specific rates of survival were made in age groups from age 10 to 54 years. The results are indeed worrying as summarized in their results chapter. “During the period from 1950 to 2021, … Read more
Very glad to announce the publication by Cambridge Scholars Press (CUP) or our book « treating autism with bumetanide” by Nouchine Hadjikhani, Eric lemonnier and myself https://www.cambridgescholars.com/product/978-1-5275-1890-2
Découvrez tous les sites de Yehezkel Ben-Ari/Discover all Yehezkel Ben-Ari websites
