As I wrote in a previous blog post, Autism Spectrum Disorders (ASDs) “originate” in utero, as we demonstrated five years ago. By retrospectively analyzing data collected in maternity wards (more than 150 non-genetic parameters) using machine learning, we can identify at birth nearly half of the babies who will have autism and all those who will … Read more
Since Thomas Bourgeron (Institut Pasteur) identified a genetic mutation linked to autism some twenty years ago, several hundred mutations have been suggested as contributing to this syndrome. Autism Spectrum Disorder (ASD) has since been classified as a genetically based syndrome, disregarding the major role of the environment. Yet despite repeated promises, and unless I am … Read more
Detecting autism at birth and identifying children likely to respond to treatment: long out of reach, these prospects are becoming concrete thanks to artificial intelligence. Driven by my work, two major French advances, both world firsts, could transform the early care and treatment of autism spectrum disorders (ASD), which affect approximately 1 in 127 children … Read more
While there is still no approved drug treatment to reduce the main symptoms of autism, a study published in the journal Translational Psychiatry shows that artificial intelligence could be a game changer. By reanalyzing data from large clinical trials previously considered negative using machine learning algorithms, researchers show that, when certain clinical profiles are taken into account, … Read more
Five French hospitals are joining the Pelargos project, led by B&A Biomedical, to revolutionize early screening for autism by analyzing data collected in maternity wards. This new step marks a decisive advance towards the large-scale validation of this artificial intelligence system. With Pelargos, France is on track to become the first country in the world … Read more
“Yehezkel Ben-Ari: The Neuroarcheology concept: From brain development to predicting, understanding, and treating brain disorders”. This is the title of an interview published by Genomic press as part of a series of portraits dedicated to the scientific and personal life of well-known scientists. it is always amazing and difficult to bring together personnal and professional … Read more
I am delighted to announce the creation of a corporate hotel on the Luminy campus – the Ben-Ari Institute for Innovation (IBEN) – which will be built by Eiffage with Rudy Ricciotti as architect and Tivoli Capital as the main financier. With 6,600 square metres of laboratories, offices and common areas, it will be a … Read more
In this work (1), the authors examined the possible relationships between metabolism and food consumed during pregnancy, and in particular during the 24th week (approximately 6 months of gestation), and the incidence of neurodevelopmental diseases such as autism and ADHD. The study examined the development of children at the age of 10 in a cohort … Read more
I am pleased to announce the publication, with my friend Etienne Danchin, of an article that criticizes the genetic view of autism and shows why we cannot ignore the crucial role of the environment during pregnancy. In our opinion, the dominance of the genetic view of autism for decades is not only based on questionable … Read more
As part of an exceptional conference organized by the Rotary Club la Ciotat Ceyreste, I will have the honor of presenting my work on autism and prenatal brain dysfunctions. Entitled “Predicting and treating autism through the concept of neuroarchaeology”, this conference will highlight fundamental discoveries that could transform the understanding and treatment of neurodevelopmental disorders. … Read more
One of the aims of both political and medical authorities is to diagnose neurodevelopmental syndromes such as autism as early as possible. Behavioural treatments are all the more effective if they start early, during the pivotal period of plasticity and learning in the first 2-3 years of life. In France, as in most other European … Read more
Despite considerable efforts and substantial investment, there are still no effective treatments for many neurological and psychiatric diseases, including autism and other developmental syndromes. There are 2 main reasons for this I) These syndromes are born in utero, which modifies the pathogenesis of the syndrome. As I have already explained, the triggering element will modify … Read more
Founded 5 years ago by the Neurochlore start-up, the non-profit IBEN fund aimed to help parents of autistic children and autism support associations. Over the 5 years of its existence, based exclusively on donations from Neurochlore, we have been able to distribute over €150K to various associations across the country, including Abashoshin , Asperanza (Brest) … Read more
In the space of 1000 days (270 days of pregnancy + 365 days for the child’s first year + 365 days for its second year), the baby will undergo incredible development! He will learn his mother tongue in utero, crawl to the breast on the day of birth, look, smile, sit, crawl, stand, walk, talk…During … Read more
I’m taking part in this meeting with the heads of CHU and innovation. I’ll be presenting our advances in the “Pelargos” project. In a nutshell, autism is “born” in utero, resulting in changes to the way the brain is constructed and later manifesting itself as the syndrome and its characteristics. As a result, we set … Read more
Prof. Yehezkel Ben-Ari will participate in BIO Europe meeting in Stockholm early November to develop partnerships with Pharma’s & investors to treat autism and brain tumors.The Co-transporter NKCC1 that regulates GABAergic inhibition and cell volume is overactive in many brain disorders including autism, fragile X and Rett syndrome, brain trauma, epilepsies, brain traumas cerebro-vascular infarcts, … Read more
The spectrum link is a large communication network involved in describing and reporting novel tools to understand and treat autism spectrum Disorders (ASD). Their correspondent has asked me to give a teamviews lecture on my observations and discovery on novel approaches and treatments of autism. I have taken this opportunity to describe several issues that … Read more
The starting point for this adventure is the well-established observation that Calcium requirements for breastfeeding generate a loss of bone formation, estimated at 10% in women and 30% in female rodents. Normally, nature is well done, estrogens compensate for this by slowing down bone resorption – remember that 3 types of bone cells contribute to … Read more
It will soon be 10 years that I have been offering this treatment for children with autism spectrum disorders with my friend Eric Lemonnier. Including our 2 successful inaugural phase 2 clinical trials, 7 other trials have been carried out around the world with, according to a meta-analysis, more than 1036 children successfully treated (Xiao … Read more
Dr Chedotal’s team (Paris Vision Institute) has already demonstrated its extraordinary abilities to study brain maturation with a tool that it masters and uses masterfully: the Light Sheet Microscope. Exploiting his proximity to hospitals and the links he has patiently developed over several years, Alain Chedotal was able to have access to human embryos (termination … Read more
To treat autism, I have often insisted on the importance of determining the electrical modifications, particularly the inaugural pathological event which occurs in utero. The concept of neuroarchaeology states that these initial events result in the persistence of neurons that remain immature – which do not mature and which disrupt brain functioning. We have thus … Read more
We like simple things in the modern, digital world, white or black, 0 or 1! Autism is either the fault of the mother or poor genetics. But both are false! the idea of the mother’s fault was born in the mind of a twisted psychologist, which has no scientific basis, if only because the syndrome … Read more
A systematic investigation of fertility around the world has recently been performed relying on 8709 country -years vital and sample registration. Age specific rates of survival were made in age groups from age 10 to 54 years. The results are indeed worrying as summarized in their results chapter. “During the period from 1950 to 2021, … Read more
Very glad to announce the publication by Cambridge Scholars Press (CUP) or our book « treating autism with bumetanide” by Nouchine Hadjikhani, Eric lemonnier and myself https://www.cambridgescholars.com/product/978-1-5275-1890-2
Many disorders are born in utero including Autism and many neurodevelopmental disorders. to understand hos they are generated and whether and how brain structures are impacted already in utero, it is instrumental to develop quantitative atlases of brain structures. IN this aim, we used the recently developed transparization (I disco) technique that enable to dissolve … Read more
IBEN will give a satellite conference at the FENS 2022, an european congress of neurosciences. The conference, which take place on July 7 and 8 at RIVE Montparnasse, will focus on the Neuroarcheology of the brain disorders and GABA signals. It will be organized by Yehezkel Ben-Ari & Nick Spitzer and will include many renowed … Read more
Our attempts to treat children with Autism Spectrum Disorders (ASD) with the NKCC1 chloride importer antagonist have met with some success with several hundreds of children treated successfully in several trial made in France, China, Sweden, Great Britain, Holland and Tunisia. Yet a large phase 3 (400 children in Europe, Brazil, Australia and US) failed. … Read more
Short video depicting the hypothesis that autism and developmental disorders are generated in utero and how identification of the alterations they produce will enable their early prediction and novel treatments.
Despite hundreds of children successfully treated in phase 2 and pilot trials around the world, the failure of phase 3 with Servier illustrates the difficulty of developing a universal treatment for autism. See the Press Release :
For decades, we have been repeatedly informed as an undisputable fact that Autism Spectrum Disorders (ASD) are “genetic”, with genetic mutations being responsible for 15 then 25% and probably all ASD. This more technical than conceptual approach has not led to a single treatment even at early stages, and no significant novel understanding of how … Read more
Découvrez tous les sites de Yehezkel Ben-Ari/Discover all Yehezkel Ben-Ari websites
