Treating Autism with Bumetanide
12 September 2023
Very glad to announce the publication by Cambridge Scholars Press (CUP) or our book « treating autism with bumetanide” by Nouchine...
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3D atlas of the mouse brain before and after birth
7 August 2022
Many disorders are born in utero including Autism and many neurodevelopmental disorders. to understand hos they are generated and whether...
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IBEN hosts a satellite conference at FENS 2022
2 May 2022
IBEN will give a satellite conference at the FENS 2022, an european congress of neurosciences. The conference, which take place...
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Bumetanide to treat brain disorders: when the empire strikes back!
3 February 2022
Our attempts to treat children with Autism Spectrum Disorders (ASD) with the NKCC1 chloride importer antagonist have met with some...
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The first 1000 days, based on the work of Yehezkel Ben-Ari
29 October 2021
Short video depicting the hypothesis that autism and developmental disorders are generated in utero and how identification of the alterations...
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Servier and Neurochlore announce the main results of the two phase 3 clinical studies assessing bumetanide in the treatment of Autism Spectrum Disorders in children and adolescents
13 September 2021
Despite hundreds of children successfully treated in phase 2 and pilot trials around the world, the failure of phase 3...
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The challenges of in-vivo GABA and glutamate measurements in the preterm neonatal brain
15 June 2021
GABA and glutamate undergo developmental changes in their organization, and for GABA even its polarity (from Excitation to Inhibition). There are...
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Cesarean Section delivery in mice leads to smaller brain volumes at birth
8 April 2021
Birth is a complex and intricate physiological process involving several mechanisms that allow a swift adaptation of the newborn to...
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There is not a single Autism-specific gene, just brain genes !
30 March 2021
For decades, we have been repeatedly informed as an undisputable fact that Autism Spectrum Disorders (ASD) are “genetic”, with genetic...
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Use of machine learning to identify at birth babies at risk of developing Autism Spectrum Disorders
25 March 2021
Autism Spectrum Disorders (ASDs) are associated with socialization and communication problems as well as restricted interests and stereotypic behavior. The...
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The Complex effects of Anti-Epileptic Drugs and Neonatal Seizures
25 February 2021
In my invited commentary in Epilepsia we discuss the original research by Kaila, Löscher and colleagues (Johne et al. 2021)...
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Of mice and men: how studying brain development helps developing treatments of autism
10 February 2021
Basic science: In 1989 we discovered that adult and immature neurons have different electrical activity with notably much lower intracellular...
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6 clinical trials now confirm the efficacy of Bumetanide to treat Autism Spectrum Disorders
17 November 2020
With three new trials published this year, there are now 6 clinical trials performed by 5 different groups that support the efficacy of Bumetanide...
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Bumetanide attenuates the severity of ASD symptomatology in Tuberous Sclerosis of Bourneville: an open study by Van Andel et al.
3 November 2020
In this trial, the authors report that a 3 months open administration of the NKCC1 chloride importer antagonist Bumetanide (0.5-1mg,...
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Antibiotherapy
12 October 2020
Antibio-therapy and autism: hypothesis and intuition are not enough We are living in a period with countless propositions of therapeutical solutions, in particular to...
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