In my invited commentary in Epilepsia we discuss the original research by Kaila, Löscher and colleagues (Johne et al. 2021) that illustrates the effects and lack of effects of Anti-Epileptic Drugs (AEDs) on asphyxia-induced neonatal seizures, and we suggest a possible scenario explaining why this happens. Using a new neonatal asphyxia model, the authors report … Read more
Awakening, a temporary revival of patients who have been akinetic, apathic and with no reaction for years following a large brain damage, has been observed after administration of drugs, but the mechanisms underlying them remain unknown. In a recent study, Arnst et al. report spectacular effects of Zolpidem on a 29 years old patient after … Read more
The new publication by the team of Christopher Gillberg in Sweden extends previous positive observations and adds important information to the numerous previous trials on using Bumetanide to treat autistic children. Even though they performed an open-label trial of just six children (3-14 years old), it is important to note that all the participants had severe ASD (CARS score above 39) without comorbidities … Read more
Basic science: In 1989 we discovered that adult and immature neurons have different electrical activity with notably much lower intracellular concentrations of chloride in the former than in the latter. High levels of chloride lead to a reduced brain inhibition and increased excitation, and are observed in immature neurons of all animal species and brain … Read more
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