Experimentation

Antibiotherapy

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Antibio-therapy and autism: hypothesis and intuition are not enough  We are living in a period with countless propositions of therapeutical solutions, in particular to treat Autism, that resemble more « fake news » and scientific pollution than actual possible treatments. It is important to remember the principles of well-established protocols on drug discovery, and to help parents navigate the unofficial announcements of possible future treatments.  A good hunch is not enough. A Nobel … Read more

There is no such thing as “gay gene” but the abyssal poverty of genetomania is alive and well

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For 40 years and the genetic revolution, it seems that everything is due to genetic mutations! There were the genes of intelligence, of crime and of course homosexuality. In a first draft, a few years ago, there were changes in the size of certain brain structures before we realized that the sample sizes made it … Read more

New paper: Fetal brain volume increases during parturition and birth in autism

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Cloarec et al, Pyramidal neurons growth and increased hippocampal volume during labor and birth in autism, Science Advances, 23rd January 2019 Yehezkel Ben-Ari and Neurochlore team demonstrate for the first time that in a naive animal, cortical and neuronal volume are not impacted by labor and birth. In contrast, in an animal model of autism, … Read more

When leptin and metabolism impact the actions of GABA on immature neurons

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An interesting observation linking metabolism with the GABA developmental shift and developmental disorders. Studying the well characterized GABA developmental shift with excitatory actions of GABA on immature neurons and inhibitory ones in adults, J-L Gaiarsa, C Porcher and colleagues have tested the hypothesis that metabolism and a major hormone controlling it -leptin- impact the time … Read more

When animal welfare is better controlled than the health of the population

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No offense to the aficionados of miracle solutions, but the discovery of new drugs requires experiments made on animal models; most often rodents or small mammals (cf this article for details).  There was a not too distant time when there was no control over the maintenance and life conditions of these animals with obvious abuses … Read more

Experimental data from mice suggest that term cesarean sections do not affect brain maturation

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In mammals, birth is one of the most biologically complex processes for both the woman and the fetus. Indeed, a complex hormonal network is set up to allow delivery, while the fetus must, at birth, quickly adjust its metabolic, hormonal, pulmonary, cardiovascular, immunological, and microbiotic functions to allow its survival. The conditions under which this … Read more

Fake news: earthworms can replace animal testing on mammals

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We live in a great world! Our goal is to simplify everything, to quickly diagnose diseases with genetics and big data, and now, we don’t even need to go through preclinical studies on mammals. These wonderful worms with a thousand cells, a super simple nervous system compared to the trillions of connections in the human … Read more

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