An interesting observation linking metabolism with the GABA developmental shift and developmental disorders. Studying the well characterized GABA developmental shift with excitatory actions of GABA on immature neurons and inhibitory ones in adults, J-L Gaiarsa, C Porcher and colleagues have tested the hypothesis that metabolism and a major hormone controlling it -leptin- impact the time … Read more
No offense to the aficionados of miracle solutions, but the discovery of new drugs requires experiments made on animal models; most often rodents or small mammals (cf this article for details). There was a not too distant time when there was no control over the maintenance and life conditions of these animals with obvious abuses … Read more
It has been three decades since we were promised the earth and since all diseases would be a thing of the past. Immortality was almost planned (by 2045) according to Kurzweil, Google’s guru; the non-genetic cognitive research was old and condemned to vegetate and be maintained by dinosaurs. It is sometimes quite funny to see … Read more
In mammals, birth is one of the most biologically complex processes for both the woman and the fetus. Indeed, a complex hormonal network is set up to allow delivery, while the fetus must, at birth, quickly adjust its metabolic, hormonal, pulmonary, cardiovascular, immunological, and microbiotic functions to allow its survival. The conditions under which this … Read more
We live in a great world! Our goal is to simplify everything, to quickly diagnose diseases with genetics and big data, and now, we don’t even need to go through preclinical studies on mammals. These wonderful worms with a thousand cells, a super simple nervous system compared to the trillions of connections in the human … Read more
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